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On the immune front, gut microbiota can increase systemic inflammation by releasing lipopolysaccharides (LPS) and proinflammatory cytokines, and they also produce amyloids, which may stimulate neural amyloid production via immune priming

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Changes of gut microbiota reflect the severity of major depressive disorder: a cross sectional study

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There is general agreement that M3 receptors are primarily responsible for the normal contraction of the urinary bladder , although M2 receptors are also present, and may act to oppose sympathetically mediated smooth muscle relaxation mediated by beta-3 receptors (Hedge, 2009

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