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some of them interact directly with NRF2, while others interact indirectly with it and directly with KEAP1 [169]

Improving CRISPR Treatments for Blood Disorders Casgevy and all the other treatments currently in trials for SCD and TDT are ex vivo: an individuals cells are taken out of the body, edited and quality-controlled in a special lab, and then put back in the patients body after they undergo intensive chemotherapy