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Arthroscopic treatment for bucket handle tears and torn discoid menisci should be offered for symptomatic patients

10.1016/j.jprot.2016.01.016 53 XiaY.CarpentierA.ChengX.BlockP

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The four-pathway approach activates mechanisms that single or dual agonists cannot reach, potentially overcoming resistance that develops with prolonged use of less comprehensive compounds

Proposed mechanisms include: DSIP-induced upregulation of downstream receptor systems that outlast the peptide itself