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(U) The point of contact for this memorandum is the undersigned at (b)(6) MATTHEW CISLER Brigadier General, U.S

The NIRS data at 8 weeks treatment were significantly improved as compared to baseline in the all patients of l-carnitine group (n = 48) (0.103 0.082 vs

A: Timeline varies individually

However, due to low BBB penetration, it has been speculated that the mechanism of action of DS2 is not associated with modulatory effects on brain resident glial cells but rather through functional changes in peripheral immune cells (Jin et al., 2013

PubMed Hjuler KF et al

Gooding JJ, 2014, 'Stimuli-responsive functionalized mesoporous silica nanoparticles for drug release in response to various biological stimuli', Biomaterials Science , 2, pp