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131 TP53 also plays a transcription-independent role to promote or inhibit ferroptosis through binding to deubiquitinase USP7 or DPP4 protein in human lung or colon cancer cells, respectively

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In the brain, hyperglycaemia activates microglia, and microglia activation and polarisation can mediate central inflammatory responses, neuronal apoptosis and exacerbate central neuropathy leading to dementia (28)

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