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SKU: 49701318066 · From ldesquadrias.com.br

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Unexpectedly, we also revealed that PIN1 can be targeted for degradation by active APC/C CDH1 in a reciprocal mechanism and that combined PIN1 and CDKs inhibition could synergistically and irreversibly activate APC/C CDH1 to induce the robust degradation of PIN1 and other mitotic proteins