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Palmitoylethanolamide (PEA) is commonly promoted for its anti-inflammatory and pain-relieving effects

You should contact your GP or NHS 111 if you experience: Persistent diarrhoea lasting more than 7 days in otherwise healthy adults Blood or mucus in stools , which may indicate inflammatory bowel disease or infection Severe abdominal pain or cramping that is worsening or different from previous digestive symptoms Unexplained weight loss alongside bowel changes Signs of allergic reaction , including rash, itching, swelling, or difficulty breathing (call 999 or go to A&E for severe reactions) Neurological symptoms such as numbness, tingling, balance problems, or memory difficulties, which may indicate B12 deficiency is not being adequately treated Seek help sooner if you have red flag symptoms, are pregnant, immunosuppressed, elderly, or have significant underlying health conditions

It has been proposed to influence nitric oxide metabolism but there is not currently good evidence supporting its use

Westergaard, L

Anti-CD38 antibody therapy: windows of opportunity yielded by the functional characteristics of the target molecule

Last reviewed: June 16, 2026 Last updated: June 16, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations