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Genetic factors to consider include: Mutations in the MTHFR gene, which can affect folate and B12 metabolism Variations in genes involved in B12 transport and utilization Understanding these factors helps doctors give better care

Juhina Farooki Clinical Dietitian

If you are experiencing hair fall and suspect B12, look for accompanying signs: Neurological: Tingling or numbness in hands and feet Memory issues or brain fog Fatigue and weakness disproportionate to activity level Hematological: Pallor, breathlessness on exertion (from anemia) Rapid heartbeat at rest Oral: Soreness or redness of the tongue (glossitis) Mouth ulcers Skin: Hyperpigmentation (particularly in darker skin tones) Premature graying B12 deficiency is associated with early hair greying as melanin synthesis requires adequate B12 If you have hair loss without any of these symptoms, androgenetic alopecia is a more likely primary diagnosis though B12 can coexist as a contributing factor

28 Co-occurring conditions like anxiety, depression, stress, and sleep disorders can be contributors, while disturbances that are difficult to diagnose, such as dysregulated stress reactivity, neurotransmitter imbalance, inflammation, mitochondrial dysfunction, free radical damage, hormonal imbalance, and metabolic disturbance, as well as crosstalk between these factors, may also play a role