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Coincidentally, it was noticed that the same intrinsic diseases as well as maladaptive changes in form and function also occur spontaneously with advancing age

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Liu T, Huang Y, Guo L, et al

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Immune system aging is often characterized by hyperreactive immune responses 64 and autoimmune inflammation, where the immune system is no longer able to properly discriminate self from non-self, resulting in increased autoreactivity 65

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Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre

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