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Methylation of the CpG islands in the NRF2 gene promoter typically suppresses NRF2 transcriptional activity, leading to reduced expression levels and impacting the cells antioxidant functions [148]

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Supplementary material The Supplementary Material for this article can be found online at: References 1 PisetskyDS

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Although not yet fully understood, the likely cause is the ionizing UV radiation spectrum of sunlight