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2001 in Endocrinology showed reduced body weight gain with 14-day AOD-9604 in obese (ob/ob) mice and identified the beta-3 adrenergic receptor dependency

10.1039/D1MD00016K 59 JacksonA

Unlike most peptides, MOTS-c originates in the mitochondria, the energy-producing centers of cells, and works by improving metabolic efficiency and stress resilience