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Clinical practice and Perfect Bs protocol use a 3-month cycle: a loading phase, a maintenance phase, and a taper, followed by a 2-month break before reassessment

Dosage timing is often set according to the study model (once daily, split doses, etc.)

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The error bars show the standard deviation of the three replicate experiments

Since these initial papers, the maze has been used to study various disease models, includingendocrine abnormalities, strokes, Alzheimers disease, other neurodegenerative diseases,and their effects on learning and memory (Brandeis et al 1989)