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La 5"-desoxiadenosilcobalamina es importante en la transformacin (isomerizacin) de la metilmalonil coenzima A en succinilcoenzima A producida por la enzima metilmalonil coenzima A mutasa con intervencin de la 5"-desoxiadenosilcobalamina, aunado a una deficiencia de metionina sintetasa y al bloqueo de la conversin de metionina a S-adenosilmetionina