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Although there are no specific studies measuring the intratesticular testosterone and DHT levels in males who are homozygous for the 5-reductase-2 mutation, semen analyses of such patients with bilaterally descended testes suggest that DHT appears to be more important in regulating semen volume and viscosity rather than playing a major role in spermatogenesis (especially if normal testosterone concentrations are present) (39)

a case control biomarker study

Toxic effect of antidepressants on male reproductive system cells: evaluation of possible fertility reduction mechanism

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Chronic inflammation plays a key role in the pathogenesis of macular degeneration, with excessive release of inflammatory factors exacerbating retinal cell apoptosis and vascular abnormalities

Orally administered berberine modulates hepatic lipid metabolism by altering microbial bile acid metabolism and the intestinal FXR signaling pathway