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Computational prediction plays a crucial role in prediction of hypothetical metabolic reactions by leveraging existing knowledge of metabolic networks, enzyme functions, and chemical transformations, which includes the homology-based enzyme function annotation 13 , constraint-based genome-scale metabolic modeling 14 , and machine learning-based prediction 15,16

This process, known as lipid peroxidation, physically degrades the structural integrity of the mitochondria

61,62,63 CDO is highly regulated at the level of protein turnover, as oxidative degradation of cysteine by CDO is highly inducible, 64 and high cysteine levels inhibit CDO ubiquitinylation and reduce its proteasomal degradation

In hospital settings, it is also used as an antidote for paracetamol overdose (IV formulation at doses of up to 150mg/kg) and in nebulized format in patients with acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis)

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943 NG/EDA significantly improves the survival rate of OGD neurons by inhibiting ferroptosis, and significantly decreases the infarct volume and neurobehavioral score of pMCAO mice