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Selected Preclinical Findings NNMT knockdown protects against DIO via increased energy expenditure and remodeled polyamine flux

Two primary tests measure the amount of B12 in blood (low in B12 deficiency): Total B12 test: measures total amount of B12 Active B12 test: measures amount of B12 that is available to the cells Two secondary tests measure function of B12 in the cell (raised in B12 deficiency): MMA: measures function of B12 in the mitochondria Homocysteine: measures function of B12 for methylation How does Vitamin B12 deficiency get diagnosed

Pinpointing Absorption Issues: Testing helps us determine if your body is failing to absorb B12 from food due to gut issues, age, or autoimmune conditions like pernicious anemia

Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author

B12 injections are most clearly indicated for people who cannot absorb B12 adequately through their gut