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The quest for systemic skin lightening logically ensued

The WHO ICD-10 uses a single, general code (G20) , which is simpler to apply but does not allow documentation of motor complications such as dyskinesia or off episodesimportant factors for tracking disease progression

Sordillo PP, Andreeff M , Helson L, Steinmetz J, Melamed MR

doi: 10.3390/ijms25010590 24

One theory is that vitamin B12 deficiency may trigger an autoimmune response in the joints, leading to inflammation and joint destruction associated with RA