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Gastrointestinal and urinary symptoms seemed not to be associated with a specific subtype

2021 Jun;16(6):64261

Obesity has a strong biological basis involving hormonal signaling, genetic predisposition, and metabolic setpoints that resist change

Significantly, these inflammatory mediators intensify intestinal inflammation locally and propagate to the brain via vagal or hematogenous routes, triggering neuroinflammation and microglial activation 31,77