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Destroying significant amounts of fat tissue could disrupt these hormonal signals in ways that are difficult to predict

Sodium nitrite administered orally or intraperitoneally to pregnant rats produced peak fetal sodium nitrite blood levels ranging from trace amounts, with a 2.5 mg/kg maternal dose and a corresponding maternal blood level of 3.9 mg/l (56-52 mol/l), to 9.4 mg/l (136.23 mol/l) with a 30 mg/kg maternal dose and a corresponding maternal blood level of 32.5 mg/l (471.01 mol/l) (Gruener et al., 1973)

Inflammatory conditions requiring the use of corticosteroids

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1 is for animals held in the laboratory under highly controlled conditions

Importantly, these mutations also led to the loss of recognition by a wide panel of monoclonal antibodies undergoing testing in the clinic [70]