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The treated animals demonstrated better collagen fiber alignment, increased tensile strength, and faster return to normal biomechanical function

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Tendon and Ligament Support: Type I collagen, the most abundant structural protein in connective tissues, helps maintain the strength and flexibility of tendons and ligaments, supporting physical performance and injury recovery

10.1016/j.lfs.2015.09.006 202

However, post-hoc stratifications revealed a possible survival benefit and slower functional decline in a subset of patients with an initial slope of ALSFRS-R greater than 0.5 points per month [36]

Follow-up experiments using kinase inhibitors applied to both LRRK2 G2019S and WT neurons in parallel to LRRK2 truncated neurons would be an interesting comparison to extrapolate the role LRRK2 plays in these observable cellular phenotypes