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Caution is advised when combining with medications that impact the immune system, as it may modulate immune responses

Regulating TAM iron metabolism within the TIME, specifically by promoting iron uptake and storage in M2-type macrophages while inhibiting iron release, allows iron accumulation in TAMs to enhance ROS production, increase p300/CBP acetyltransferase activity, and promote p53 acetylation

The mutant protein was purified by using BeyoGold TM His tag purification resin (denaturant resistant) (P2233, Beyotime Biotechnology, Shanghai, China) according to the manufacturer's protocol

10.1016/j.celrep.2016.12.055 11 Burgos-BarraganG.WitN.MeiserJ.DinglerF

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Both FRDA fibroblast cell lines showed reduced expression levels of the mitochondrial subunits, NDUFS1 and SDHB compared to control, which could be explained by the Fe-S cluster deficit