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At the same time, reduced IDO activity reduced kynurenine and further weakened peripheral immune tolerance, which played a driving role in the hypothyroidism immune disorder caused by the imbalance of the whole gut microbiota (Clarke et al., 2017)

These challenges have driven research into alternative delivery methods

The CFDS slope represented posterior attenuation of the deep liver parenchyma

One such approach involved the development of an acid-responsive platform by crosslinking phenylalanine and acrylamide derivatives into injectable precursors