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Choline is an essential nutrient which is absorbed in the upper small intestine by specific enterocyte transporters via facilitated (Radziejewska and Chmurzynska, 2019), only excessive amounts are metabolized into TMA by the gut microbiota in the colon (Papandreou et al., 2020)

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A 2024 study in the British Journal of Dermatology demonstrated that skin barrier dysfunction activates the NLRC4 inflammasome, creating a vicious cycle of inflammation that makes the skin highly reactive, sensitive, and prone to chronic rashes or severe acne breakouts

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