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Once succinyl-CoA enters the Krebs cycle, it facilitates the production of reducing equivalents like NADH and FADH2

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NICE and BNF Guidance: You correctly point out that even official guidance from NICE and the BNF acknowledges that some individuals may require more frequent injections

Rapid intravenous injection may result in cardiac arrhythmias and in severely toxic cows, collapse and death

Inborn errors of metabolism (e.g., vitamin B6-dependent convulsions or B6-responsive anemia)

People taking certain common medications including metformin for blood sugar management and proton pump inhibitors for acid reflux also face increased deficiency risk