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HR, hazard ratio

10.1542/peds.113.5.e465 68

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Downregulation of Parkin in various cancers results in PHGDH protein accumulation and SSP activation, thus driving tumorigenesis (108, 109)

Given that mitochondria are essential for tumorigenesis and cancer cell proliferation (3133), targeting the mitochondrial OXPHOS metabolic pathway may be a viable approach for inhibiting the growth of cancer cells (34)

There is evidence suggesting that OVs can influence macrophage polarization, shifting pro-tumorigenic M2 macrophages toward an anti-tumorigenic M1 phenotype