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Next, we investigated the regulation of lipid metabolism, and we observed increased expression of molecules involved in fatty acid uptake (fatty acid transport protein 1, cluster of differentiation 36), oxidation (peroxisome proliferator-activated receptor alpha), de novo lipogenesis (fatty acid synthase), and hepatic lipid export (apolipoprotein B, phosphatidylethanolamine N-methyltransferase) in alcohol-treated APP/PS1 mice compared to APP/PS1 alone or alcohol-treated WT mice

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All other antibodies were purchased from Sigma, Santa Cruz (Santa Cruz, CA) or Abcam (Cambridge, MA)