Disclosure of interest: Daizo Ishii: nothing to disclose, Takeshi Hara: nothing to disclose, Masashi Kuwabara: nothing to disclose, Hiroshi Kondo: nothing to disclose, Shinji Kume: nothing to disclose, Nobutaka Horie: nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.01 - DIAGNOSIS/INVESTIGATION OF STROKE ETIOLOGY P356 - ESOC25-1269 ETIOLOGICAL DIFFERENCES IN CLOT CONTRACTION MARKERS: COAGULATION FACTOR XIIIa AND MYOSIN-9 IN ACUTE ISCHEMIC STROKE CLOTS Duaa Jabrah 1 , Abhay Pandit 2 , Ray McCarthy 3 , Michael Gilvarry 3 ,Petra Redfors 4 , Katarina Jood 4 , Andrs Nagy 5 , Sarah Power 6 , Klearchos Psychogios 7 , Georgios Tsivgoulis 8 , Istvan Szikora 5 , Turgut Tatlisumak 4 , Alexandros Rentzos 9 , John Thornton 6 , Karen Doyle *1,2 1 Department of Physiology, University of Galway, Galway, Ireland, 2 CRAMResearch Ireland Centre for Research in Medical Devices, University of Galway, Galway, Ireland, 3 Johnson and Johnson Medtech, Neurovascular, Research and Development Department, Galway, Ireland, 4 Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden, 5 Department of Neurointerventions, National Institute of Neurosciences, Budapest, Hungary, 6 Department of Radiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland, 7 Stroke Unit, Metropolitan Hospital, Piraeus, Greece, 8 Second Department of Neurology, National & Kapodistrian University of Athens, Athens, Greece, 9 Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Institute of Clinical Sciences, Department of Radiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Background and Aims: There is evidence that acute ischemic stroke (AIS) clots may undergo a process of clot contraction, resulting in distinct features such as low porosity and polyhedral erythrocytes
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Organic acid refers to weak acids that do not dissociate completely in water but are generally soluble in organic solvents and are mostly carboxylic acids
In the basal state PNPLA2 has weak hydrolytic activity which is greatly increased by the co-lipase alpha/beta hydrolase domain-containing protein 5 (ABHD5, also known as CGI-58) by greater than 20-fold (30)
