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Description

The opposite effect occurs at the adult stage (P56P70), during which wild-type mice show robust LTP and LTD compared to MET cKO mice in which LTP and LTD are markedly decreased

Because of this endocrine effect and risk of serious liver toxicity, oral ketoconazole is now rarely usedexcept in select cases like Cushings syndrome management

There are also generic forms of Fosamax available that have different dosages than brand-name Fosamax does

Further research is needed to improve our understanding of their effects on obesity-related comorbidities and the underlying mechanism, whether involving direct effects on target tissues or mediated by improvement in BW, glucose levels and other CV risk factors