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Rather than functioning solely as a metabolic by-product, lactate acts as a central signalling metabolite that integrates epigenetic reprogramming, mitochondrial dysfunction, cell death pathways, and immune-fibrotic feedback mechanisms to drive progressive tubular injury

10.1038/s41418-017-0053-8 Cell Death Differ

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Sigma-1 receptor knockout impairs neurogenesis in dentate gyrus of adult hippocampus via down-regulation of NMDA receptors

According to relevant reports, a large amount of ROS may be produced in the testicular cells of patients with diabetes, resulting in damage to mitochondrial function and the consumption of a large number of antioxidant enzymes

Tectorigenin Tectorigenin, a methoxy-isoflavone, has shown significant potential in alleviating symptoms of asthma through its anti-inflammatory and antioxidative properties