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The potential role of adjuvant therapy that may help ameliorate the effects of residual inflammation such a reduced presence of antioxidants or the consequences of prior injury causing impairment of cellular homeostasis is less well-understood

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Agents that inhibit the cystine uptake via the cystine/glutamate antiporter (system x c - ) (e.g., sulfasalazine) or directly deplete the GSH from plasma (e.g., cyst(e)inase) triggers ferroptosis and arrests tumorigenesis [224, 225]

On the molecular level, clock genes and their protein products oscillate to generate these circadian rhythms