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Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17-hydroxylase-17,20-lyase (CYP17)part II: core rigidification and influence of substituents at the methylene bridge

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Cavalcante G.C., Schaan A.P., Cabral G.F., Santana-da-Silva M.N., Pinto P., Vidal A.F., Ribeiro-dos-Santos

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97, 98 Indeed, the RhoA/ROCK pathway has been shown to be involved in the formation of atherosclerotic lesions, vasoconstriction and myocardial hypertrophy and to be activated in patients with hypertension and in patients with coronary artery disease

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Mol Genet Metab 114(1):7379