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Hepatocytes exhibited nearly normal morphology, with only mild vacuolization (black arrow) and minimal fatty change

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In: Rubio, I., Prior, I

Our finding that LTC 4 receptor antagonists greatly reduced the level of NOX4 under extensive ER stress but had no effect on its basal expression level is in line with the dual opposite role of NOX4-generated ROS

These findings suggest that stress-induced graying may be temporarily reversible, providing a novel avenue for therapeutic development

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