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Future research, driven by advanced models, biomarker development, and clinical trials, will pave the way for innovative treatments that balance modulation of angiogenesis with preservation of neuronal homeostasis

Haem/iron acquisition systems and evidence for their role in NTHi pathogenesis are summarised in Table 1 , Figure 2

Glutathione Determination Glutathione and GSH disulfide (GSSG) contents were assayed using the fluorometric o-phthalaldehyde (OPA) method (Senft et al., 2000), which was previously proven in our laboratory by HPLC [18], using 96-well black microplates

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Hannigan) 63 ) incubation was carried out overnight at 4 C