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[3] Jastreboff, A.M., et al

PloS One 13 (8):e0201136 Zhang CR, Zhu WN, Tao W, Lin WQ, Cheng CC, Deng H, Ni GX (2021) Moxibustion against cyclophosphamideinduced premature ovarian failure in rats through inhibiting NLRP3/caspase1/GSDMDdependent pyroptosis

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Each receptor binding interface places different demands on the peptide sequence, and the design process must simultaneously satisfy three sets of structure-activity constraints

Other studies in the same era found that improvement did not reach clinically significant differences from placebo