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Why Metabolic Safety Matters Full-length human growth hormone therapy carries well-documented metabolic risks including IGF-1 elevation, impaired glucose tolerance, and increased diabetes risk

doi: 10.3389/fmicb.2026.1751932 Received 22 November 2025 Revised 20 January 2026 Accepted 22 January 2026 Published 23 February 2026 Volume 17 - 2026 Edited by Bijay Kumar Behera, Central Inland Fisheries Research Institute (ICAR), India Reviewed by Manivannan Paramasivan, Bharathidasan University, India Walter Jose Martinez Burgos, National Institute of Amazonian Research (INPA), Brazil Updates Copyright 2026 Srivastava, Mir, Hussain, Mitra, Srivastava, Kumar and Kaur

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Recently, the role of this cell death modality in the pathogenesis of various diseases has garnered increasing attention (epelak et al., 2020)

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While strongly linked to increased cancer risk, the interaction between smoking, HPV infection, and cancer development warrants further research due to some conflicting findings