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Thus, nanoparticles with lipophilic properties can cross the BBB more efficiently and are able to deliver drug molecules adequately into the brain parenchyma[71, 72]

That's why it carries risks like insulin resistance, joint pain, and soft tissue overgrowth

To induce differentiation, cells were grown to confluence and subsequently cultured in medium as above, but without FBS and containing 0.01 mg/ml transferrin, 1 M cortisol, 200 pM triiodothyronine (T3), 20 nM human insulin, 0.25 M DEX, 500 M IBMX, and rosiglitazone (2 M until day 4, 1 M until day 8, then without rosiglitazone) (all Sigma St

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