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As one of the most important dopamine-replacement therapies for PD, L-DOPA is commonly given with carbidopa to improve bioavailability and avoid early conversion into dopamine before penetration into the brain (Gandhi and Saadabadi, 2025)

The GSH:GSSG ratio was normalized by taking the square root of the variable

Just as low intracellular glutathione levels (as observed in many cancer cells) can decrease antioxidant capacity 9 , elevated levels of glutathione are shown to increase antioxidant capacity 10 and improve resistance to oxidative stress

Emerging evidence suggests that the MGBA might also play a key role in these effects

Abnormal A accumulation exacerbates ROS production and induces OS, further contributing to redox imbalance in the AD brain (Sharma and Kim, 2021)

Figure 6