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Zhu et al, 1993 46 accounted the high levels of GPx following protein deficiency due to its low utilization and increase in synthesis

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These distinct remodeling patterns carry significant clinical implications, with eccentric hypertrophy often evolving into HFrEF and concentric hypertrophy predominantly associated with HFpEF[46]

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They can also respond to intracellular events such as ROS or intracellular receptors (Torres, 2003)