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Also, p62 recruited to the damaged mitochondria ubiquitinates Mcl-1, leading to its degradation and activation of apoptosis [305]

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Apiradee U, Shina Q, Natdanai M, et al

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It remains not clear why this surface residue Cys396, located far away from the monomer interaction could lead to monomerization

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This is relevant, as platelets are the first cells that arrive at a site of injury to release various factors that initiate the repair process

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Common examples include: These are designed to mimic or enhance the bodys own signaling molecules while extending their activity through modifications like PEGylation , fatty acid chains , or amino acid substitutions

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