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Additionally, crosslinking density, polymer hydrophobicity, and nanoparticle size distribution are often overlooked variables that critically affect responsiveness and cytotoxicity

however, no substantial progress has been made in clinical practice

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*Correspondence: Tim Rolph, [email protected] This article was submitted to Obesity, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

756 Overexpression of ACSL4 exacerbates cerebral I/R injury in rodents, while genetic or pharmacological reduction of ACSL4 effectively prevents cerebral I/R injury

In addition, NRF2 is regulated by the cytoplasmic inhibitor Kelch-like ECH-associating protein 1 (KEAP1)