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Moreover, the engagement of the sympathetic nervous system, in other words, the fight-or-flight mechanism, irrespective of the underlying trigger, is also almost always accompanied by a reduction in fat utilization and an increase in carbohydrate metabolism

Signal Amplification: Activated receptors trigger G-protein coupling, adenylyl cyclase activation, and dramatic increases in intracellular cAMP (often 10-100 fold elevation)

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So what should you do for your sciatica instead of a cortisone shot

Gastroenterology 146 , 726735 (2014)