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Int J Mol Sci (2014) 15:1955261.10.3390/ijms151119552 46 EkanayakeAKesterJJLiJJZehentbauerGNBunkePRZentJB

Expression of this mutated gene greatly reduces expression and operation of astrocytic glutamate transporters, thus leading to an excitotoxicity linked to psychosocial abnormalities and impaired cognition