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Osteosarcoma stem cells resist chemotherapy by maintaining mitochondrial dynamic stability via DRP1

I don't know what that is, but maybe it's just no sauce

Drug metabolism involves the chemical biotransformation of parent drugs molecules, commonly through phase I reactions (catalyzed by CYP450 and FMO enzymes) and phase II reactions (involving conjugation reactions driven by UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, glutathione S-transferases and methyltransferases), leading to more hydrophilic, usually inactive compounds, that are more readily excreted from the liver into urine and feces ( Hence, one way to monitor the harmful effects of a xenobiotic on hepatocytes is by examining the intracellular metabolome

doi: 10.1186/s12943-025-02339-1 11 LiJHuJYangYZhangHLiuYFangYet al

We got a grab a book from our local library but I think I learned more from this post

Acute care hospitals may participate in the BPCI Advanced model in one of two capacities: as a model Participant or as a downstream Episode Initiator