hypothesis glutathione persister cells Drug-tolerant in cancer: the cutting edges and future directions Plasticity, signaling, and metabolic rewiring

(2009) 124:e43949

doi: 10.3389/fvets.2022.854890 41 ChenYYangJHuangZYinBUmarTYangCet al

The expression of lncRNA CRNDE negatively correlates with profibrotic genes, for example, and its overexpression has been shown to reduce cardiac fibrosis and improve contractile function in DCM mice (143)

have revealed that ferroptosis regulates PD-L1 expression in HNSCC through a dual mechanism: on the one hand, PD-L1 is upregulated via the ROS-driven NF-B signaling pathway (a membrane damage-independent pathway), and on the other hand, immune checkpoint molecule expression is promoted through ferroptosis stress-induced calcium influx (a membrane damage-dependent pathway)

633 Chronic social defeat stress-induced depressed mice showed iron accumulation and iron homeostasis imbalance in the brain, accompanied by downregulation of GSH levels and GPX4 expression, which may be a potential mechanism of lipid peroxidation and ferroptosis in depressed mice

Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs