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The dotted line at a ratio of 1.4, indicates that the amount in brain equals the amount originating from blood [36]

The Wnt/-catenin signaling pathway is another critical driver of GC development and metastasis

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Due to the increased glutamate concentration in the protruding gap, NMDAR on astrocytes cannot drive the intracellular mechanism to exert a neuroprotective effect, resulting in a reduction in the supply of antioxidant glutathione induced by this mechanism, which further strengthens the toxic effect of glutamic acid (52)