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Paralleling the decreases in BH 4 , reductions of eNOS activity were seen of 58, 86, or 92% and NOS-derived superoxide production were greatly increased [15]

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On the basis of insights gained from our previous model of HSV-1 gB, which was determined using a stabilizing helix breaker mutation (H516P) in the central helix of domain III (DIII) 16 , we devised mutations that use different means of stabilization 29 (Fig

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479 A preclinical study indicated that, 480 adjunctive treatment with SG1002 can enhance circulating and tissue levels of H 2 S, alleviating cardiac dysfunction in HFpEF and significantly reducing cardiac interstitial fibrosis