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Description

PEGylation has also been shown to increase the bioavailability or the half-life of therapeutics in the plasma [8,9], including anticancer therapeutics [10]

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doi: 10.1002/1099-1263(200011/12)20:6 3.0.co;2-o

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elegans mutant Guide RNA sequences were designed using 41 and genome editing was performed as described previously 42,43

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Although powdered garlic supplements do not actually contain allicin, the manufacturer may provide a value for the "allicin potential" or "allicin yield" of a supplement on the label

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Clinically, G6PD deficiency has been linked to increased risk of Hepatitis A and B infections (99, 100), which may be related to deficient interferon responses in hepatocytes due to insufficient ROS generation by NADPH oxidase, as has been described for Dengue virus infection in G6PD-deficient monocytes (101)

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Acknowledgements We are sincerely grateful to all the staff of ShanghaiTech University and Headache Center, Beiling Tiantan Hospital, CapitaMedical University, We thank the Molecular lmaging Core Facility (MICF) at the School of Life Science and Technology, Shanghaitech Universitv for providing technical support, We thank Wei wang, Xiao Ren and Yiving liu for comments on themanuscript

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