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This approach categorizes internal tumor cells into distinct subclones, revealing the internal heterogeneity of GBM

Moreover, this inert glutamine metabolism was accompanied with the down-regulation of GLS, thereby reducing the hydrolysis of glutamine and the generation of its derivative glutamate

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Induction of heme oxygenase-1 inhibits NAD(P) H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability

In patients with no CMV-specific immune reactivity at baseline (n = 31) expansion of CMV-specific T-cells was demonstrated in 20 (64.5%) within 100 days (145)