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Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique

In hepatocytes, acetyl-CoA is used as a substrate for ketogenesis [37] during extended fasting or limited carbohydrate availability, and the liver adapts to dwindling glycogen stores by increasing -oxidation and by converting the acetyl-CoA to ketone bodies, primarily acetoacetate and its chemically reduced analog -hydroxybutyrate [38]

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Russo, S., Scotto Di Carlo, F