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Blanco et al

Specific blockade of NLRP3-mediated pyroptosis occurs upon the removal of copper, which may be related to the downregulation of copper-dependent SOD1 activity (147)

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However, due to the insufficient number of tumor-specific effector T cells in the patient's body and the inhibitory effect of the tumor immune suppressive microenvironment on immune cells, not all patients respond to immunotherapy